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KMID : 0613820160260101130
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Journal of Life Science
2016 Volume.26 No. 10 p.1130 ~ p.1136
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Anti-proliferative Effects of Acid Extract of Gracilaria Verrucosa on Primary Human Prostate Cancer Cells
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Hong Seong-Min
Cho Hyun-Dong
Kim Jeong-Ho
Lee Ju-Hye
Song Woo-Si
Yee Sung-Tae
Lee Mi-Kyung
Seo Kwon-Il
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Abstract
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The purpose of this study was to investigate the anti-proliferative and apoptotic effects of acid extract of Gracilaria verrucosa (AEG) on RC-58T/h/SA#4 primary human prostate cancer cells. AEG significantly decreased the cell viability of prostate cancer cells in a dose-dependent manner. AEG also showed relatively low cytotoxicity on normal cell (RWPE-1). The morphology of prostate cancer cells treated with AEG was distorted to shrunken cell masses. In addition, it was revealed that AEG induced cell death as evidenced by increased formation of apoptotic body and nuclear condensation. Furthermore, AEG clearly modulated the down regulation of Bcl-2 (anti-apoptotic)/Bax (pro-apoptotic) family and activated caspase-3 as an effector caspase in a dose-dependent manner. AEG inhibited cell proliferation induced by environmental hormones as a bisphenol A in a dose-dependent manner. These results indicate that AEG act as anti-proliferative effects as a potential therapeutic agent on primary human prostate cancer cells.
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KEYWORD
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Anti-proliferative effect, apoptosis, environmental hormone, Gracilaria verrucosa
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